Differential Requirements for MCM Proteins in DNA Replication
September 05, 2007
Bibliography: Gilles Crevel, Reina Hashimoto, Sharron Vass, Jacob S. Sherkow, Masamitsu Yamaguchi, Margarete M.S. Heck, Sue Cotterill, Differential Requirements for MCM Proteins in DNA Replication in Drosophila S2 Cells, 2 PLoS ONE 833 (2007).
The MCM2-7 proteins are crucial components of the pre replication complex (preRC) in eukaryotes. Since they are significantly more abundant than other preRC components, we were interested in determining whether the entire cellular content was necessary for DNA replication in vivo.