Differential Requirements for MCM Proteins in DNA Replication

Details

Author(s):
  • Jacob S. Sherkow
  • Gilles Crevel
  • Reina Hashimoto
  • Sharron Vass
  • Masamitsu Yamaguchi
  • Margarete M.S. Heck
  • Sue Cotterill
Publish Date:
September 5, 2007
Publication Title:
PLoS ONE
Format:
Journal Article Volume 2 Page(s) 833
Citation(s):
  • Gilles Crevel, Reina Hashimoto, Sharron Vass, Jacob S. Sherkow, Masamitsu Yamaguchi, Margarete M.S. Heck, and Sue Cotterill, Differential Requirements for MCM Proteins in DNA Replication in Drosophila S2 Cells, 2 PLoS ONE 833 (2007).
Related Organization(s):
Link(s):
Read More

Abstract

The MCM2-7 proteins are crucial components of the pre replication complex (preRC) in eukaryotes. Since they are significantly more abundant than other preRC components, we were interested in determining whether the entire cellular content was necessary for DNA replication in vivo.